Numerical Study on Cooling and Crystallization Characteristics of Solid Surface Vitrification Method

Numerical Study on Cooling and Crystallization Characteristics of Solid Surface Vitrification Method

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Solid surface vitrification (SSV) has been increasingly applied in the field of cell cryopreservation.However, most studies based on empirical experimentations have not included simulation analysis and physical mechanism explanation, consequently affecting the universality of the designs and innovation efficiency in SSV-related technologies.This study focused on the non-isothermal crystallization characteristics and established a thermal diffusion model of SSV coupled with a non-isothermal crystallization source.A propylene glycol solution with the mass fraction of 35% was selected as the sample for analysis.Additionally, the effects of the pre-cooling iphone 14 price miami temperature, sample volume, and sample shape on the temperature and crystallization iphone 13 atlanta characteristics of the SSV method were investigated.

The results show that the established model can directly reveal change patterns of the temperature and the crystallinity inside the sample during the freezing process.The region most likely to undergo crystallization is located at the upper part of the sample away from the precooled surface, and the most crystallizable region is not necessarily located at the top of the droplet sample.Furthermore, vitrification of the sample is easier to achieve because of the lower precooling temperature, smaller sample volume, and flatter shape.